Two new point mutations at A2062 associated with resistance to 16-membered macrolide antibiotics in mutant strains of Mycoplasma hominis.
نویسندگان
چکیده
We describe two mutants of Mycoplasma hominis PG-21 which show resistance to 16-membered macrolides but susceptibility to lincosamides, obtained by in vitro exposure to increasing doses of josamycin. The 23S rRNA gene showed that each had a mutation (A2062G and A2062T) corresponding to nucleotide 2062 in Escherichia coli, which was associated with the acquired phenotype.
منابع مشابه
Genetic basis of natural resistance to erythromycin in Mycoplasma hominis.
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متن کاملThe structures of four macrolide antibiotics bound to the large ribosomal subunit.
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متن کاملSingle and dual mutations at positions 2058, 2503 and 2504 of 23S rRNA and their relationship to resistance to antibiotics that target the large ribosomal subunit.
OBJECTIVES To study mutations at positions A2058, A2503 and U2504 (Escherichia coli numbering) of 23S rRNA and their relationship to resistance to antibiotics that target the large ribosomal subunit. METHODS Single and dual mutations at positions 2058, 2503 and 2504 of 23S rRNA were introduced into a Mycobacterium smegmatis strain with a single functional rRNA operon. MICs of macrolide, pleur...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 45 10 شماره
صفحات -
تاریخ انتشار 2001